Table 4 RCTs included in meta-analysis Left Hippocampus
From: Effect of cannabinoids on glutamate levels in the human brain: a systematic review and meta-analysis
Article | Imaging Modality and Parameters | OUTCOMES | REPORTED CONCLUSIONS | |||
|---|---|---|---|---|---|---|
Glx | Glu | Glx/Cre | Glu/Cre | |||
Colizzi et al. 2020 | 1H-MRS 3 T Voxel: left hippocampus (20 × 20x15 mm3) PRESS spectra analysed using LCModel v6.3 - 1L |
|
|
| Â | THC did not affect glutamate levels (Glx, Glu, Glx/Cre) in left hippocampus |
Davies et al. 2023 | 1H-MRS 3 T Voxel: left hippocampus (20 × 20x15 mm3) PRESS spectra analysed using LCModel 6.3 - 0 A |  |
| Â | Â | CBD did not affect glutamate levels, although CBD treated group had reduced psychotic symptoms |
O'Neill et al. 2021 | 3 T Voxel: left hippocampus (20 × 20x15 mm3) PRESS spectra analysed using LCModel v6.3 - 1L |
|
| Â | Â | CBD increased Glu level in the hippocampus but not Glx |
Solowij et al. 2015 | nd | Â |
| Â | Â | CBD increased Glu level in left hippocampus |
- Legend:
Reported increase,
Reported decrease,
No difference reported, ACC anterior cingulate cortex, Cap Capsule, CBD Cannabidiol, CBDV Cannabidivarin, COT Crossover (double-blind, randomized, controlled) trial, CS Cross sectional observational study, CU Cannabis user, dmpfc Dorsomedial prefrontal cortex, EP Early psychosis, F Female, Glu Glutamate, Glu/Cre Glutamate/creatine ratio, Glx Glutamine/glutamate, HChealthy control, HIV Human immunodeficiency virus, Inh Inhalation, IV Intravenous, L Left, liq Liquid, MDMA Methylenedioxymethamphetamine, MEGA-PRESS MEscher- GArwood Point RESolved Spectroscopy, nd no data provided, NU Noncannabis user, po per os (oral), PRESS Point RESolved Spectroscopy, RCT Randomized controlled trial (parallel group), STEAM Stacked stimulated echo acquisition mode, THC tetrahydrocannabinol, 1H-MRS Proton magnetic resonance spectroscopy, PRESS Point RESolved Spectroscopy
Reported increase,
Reported decrease,
No difference reported, ACC anterior cingulate cortex, Cap Capsule, CBD Cannabidiol, CBDV Cannabidivarin, COT Crossover (double-blind, randomized, controlled) trial, CS Cross sectional observational study, CU Cannabis user, dmpfc Dorsomedial prefrontal cortex, EP Early psychosis, F Female, Glu Glutamate, Glu/Cre Glutamate/creatine ratio, Glx Glutamine/glutamate, HChealthy control, HIV Human immunodeficiency virus, Inh Inhalation, IV Intravenous, L Left, liq Liquid, MDMA Methylenedioxymethamphetamine, MEGA-PRESS MEscher- GArwood Point RESolved Spectroscopy, nd no data provided, NU Noncannabis user, po per os (oral), PRESS Point RESolved Spectroscopy, RCT Randomized controlled trial (parallel group), STEAM Stacked stimulated echo acquisition mode, THC tetrahydrocannabinol, 1H-MRS Proton magnetic resonance spectroscopy, PRESS Point RESolved Spectroscopy