Table 1 CBD interacts with the endocannabinoid system

FAAH

Fatty acid amide hydrolase

Antagonism

Bisogno et al. 2001; Petrocellis et al. 2011)

CB₁

Cannabinoid receptor type 1

Inverse agonism, Negative allosteric modulator,

Blocks

Navarro et al. 2020; Laprairie et al. 2015; Thomas et al. 2007)

CB₂

Cannabinoid receptor type 2

Inverse agonism

Thomas et al. 2007)

Heterodimerization of CB₂/5HT_1A

Interaction

Pazos et al. 2013)

CB₁R internalization

Affects the kinetics

Navarro et al. 2020)