Table 3 Distribution of CYP450 metabolism phenotypes in the sample

CYP2C9 

 Poor metabolizer activity score 0 

0 

 Poor metabolizer activity score 0.5 

1 

  *2/*3 

1 

 Intermediate metabolizer activity score 1.0 

12 

  *1/*3 

12 

 Intermediate metabolizer activity score 1.5 

18 

  *1/*2 

18 

 Normal metabolizer 

40 

  *1/*1 

40 

CYP2C19

 Poor metabolizer 

1 

  *2/*2

1 

 Intermediate metabolizer

15 

  *1/*2 

15 

 Intermediate to normal metabolizer

7 

  *2/*17 

7 

 Normal metabolizer 

34 

  *1/*1 

34 

 Rapid metabolizer 

12 

  *1/*17 

12 

 Ultrarapid metabolizer 

2 

  *17/*17 

2 

CYP3A4 

 Intermediate to normal metabolizer 

6 

  *1/*22 

5 

  *1/novel allele with heterozygous c.200A>G, p.Lys67Arg 

1 

 Normal metabolizer 

65 

  *1/*1 

65 

CYP3A5

 Poor metabolizer 

56 

  *3/*3 

55 

  *3/*3 with a heterozygous c.1111A>G, p.Ile371Val

1 

 Intermediate metabolizer 

15 

  *1/*3 

15