Hypothesized pharmacogenomic and medication influences on tetrahydrocannabinol and cannabidiol metabolism in a cohort of unselected oral cannabis users

Table 1 Phenotype of genes encoding CYP450 enzymes, their function, and hypothesized effect on THC and CBD metabolism (PHARMGKB n.d.).

Phenotype	Function*	Hypothesized effect on THC/CBD metabolism
Poor metabolizer	Greatly reduced to no function of the CYP enzyme	Decreased metabolism of THC or CBD
Intermediate metabolizer	Moderately reduced function of the CYP enzyme	Decreased metabolism of THC or CBD
Intermediate to normal metabolizer	Mildly reduced function of the CYP enzyme	Decreased metabolism of THC or CBD
Rapid metabolizer	Moderately increased function of the CYP enzyme	Increased metabolism of THC or CBD
Ultrarapid metabolizer	Greatly increased function of the CYP enzyme	Increased metabolism of THC or CBD

Abbreviations: CBD cannabidiol, THC tetrahydrocannabinol
*Applies to CYP2C9, CYP2C19, and CYP3A4 but not CYP3A5. In the case of CYP3A5, intermediate and normal metabolizer phenotypes results in increased function and metabolism of the CYP enzyme

ISSN: 2522-5782