Fig. 7

The synthetic cannabinoid MMB-2201 increased the release of VEGF, ANG-1, and ANG-2 from endothelial cells. VEGF, ANG-1, and ANG-2 release from HBEC-5i was investigated using ELISA. The release of these proteins was significantly increased at different concentrations of MMB-2201. Data are presented as mean ± SEM (n = 3). (*) indicates p < 0.05. (**) indicates p < 0.01. (***) indicates p < 0.001. (****) indicates p < 0.0001