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Table 1 IC50values of screened cell lines

From: Cannabidiol’s cytotoxicity in pancreatic cancer is induced via an upregulation of ceramide synthase 1 and ER stress

Cell line

48 h

72 h

h- Panc03.27

CBD – 32.32 ± 0.3

CBD – 26.51 ± 0.9

GEM – 0.012 ± 0.2

GEM – 0.008 ± 0.5

h- Panc1

CBD – 20.8 ± 0.9

CBD – 19.9 ± 0.6

GEM – 0.53 ± 0.7

GEM – 0.13 ± 0.7

m-3275

CBD – 21.4 ± 0.5

CBD – 17.19 ± 0.8

GEM – 0.06 ± 0.3

GEM – 0.04 ± 0.5

h- HPAF-II

CBD – 23.4 ± 0.9

CBD – 18.8 ± 0.1

GEM – 0.25 ± 0.4

GEM – 0.09 ± 0.4

h- CFPAC-I

CBD – 14.9 ± 0.1

CBD – 12.7 ± 0.9

GEM – 0.013 ± 0.3

GEM – 0.009 ± 0.6

h-H6c7 (HPDE)

CBD – 55 ± 0.2

CBD – 51 ± 1.2

h-IMR-90

CBD – 50 ± 0.7

CBD – 47 ± 0.4

  1. Various pancreatic cancer cell lines both human (h-) and murine (m-) and IMR-90 inhibitory concentration values following treatment with CBD and GEM = gemcitabine, over 48 and 72 h. Data shown as µM and represents three independent experiments performed as quadruplicates as IC50 ± SEM values from cell-titre glo assay (SRB assay produced similar IC50, data not shown)